07.06.2018    14:00

SR25, Im Neuenheimer Feld 328, Heidelberg

 

Neurobiology Lecture

 

Secreted signals that coordinate glioblastoma progression and neurodegeneration

 

Sergio Casas-Tintó
Assistant professor
Molecular, Cellular and Developmental Department
Cajal Institute (CSIC)
Madrid, Spain

 

Glioblastoma (GB) is the most common and lethal type of cancer of the central nervous system and it is characterized by its aggressiveness, rapid cell proliferation and great infiltration capacity. GB causes progressive neurological dysfunction including memory loss, speech and language defects, epileptic seizures and vomits.  GB cells develop a network of tumor microtubes (TMs) which confers resistance to the radiotherapy, contribute to the proliferation and dissemination of the tumor and provokes the degeneration of the neighboring neurons. Our data show that TMs mediate WNT pathway disruption both in GB and neurons. WNT pathway plays a central role in GB progression and concomitant neurodegeneration. Frizzled receptors accumulate in TMs to deplete WNT from neurons. As a consequence GB cells proliferate and, in parallel, neurons undergo synapse loss and functional degeneration. We propose the study of WNT and other signals that mediate GB and neuron communication as a novel strategy against GB.

 

13.06.2018    13:00

Neurobiology Lecture

 

Role of prefrontal cortex parvalbumin interneurons in cognitive processing – a postdoc project at Boehringer Ingelheim

 

Dr. Oana-Daniela Toader
CNS DiseasesBoehringer Ingelheim Pharma GmbH
Biberach

 

Cognitive dysfunction is a common symptom of neuropsychiatric disorders such as schizophrenia and Alzheimer's disease. To date, currently available drugs cannot, or only insufficiently treat cognitive impairment. Cognitive impairments were shown to correlate with a decline in the expression of parvalbumin (PV) in the prefrontal cortex (PFC) of patients suffering from schizophrenia. Parvalbumin is an activity-dependent protein that acts as a calcium buffer in a subpopulation of inhibitory interneurons. These neurons are thought to be essential for neuronal network function and generating gamma oscillations. In light of these findings, we aim to establish a mouse model for testing potential cognitive enhancing drug candidates, based on a neuronal circuit & symptoms approach. We plan to target fast spiking (FS) PV+ interneurons in the medial PFC of mice (mPFC) via an optogenetic approach (using a light-activatable inhibitory protein, Arch) in order to disturb prefrontal network function, i.e. gamma oscillations. We will subsequently phenotype these mice by using a battery of behavioral & cognitive tests while probing network (i.e. gamma oscillations) and single neuron (i.e. firing pattern, synchronicity with behavioral events and local oscillations) function. Subsequently, we plan to rescue the optogenetically induced impairments by using cognitive enhancing drugs. To this aim, we will assess both cognitive performance and neuronal network function.

 

HS2, Im Neuenheimer Feld 306, Heidelberg

 
IZN Career advice from the experienced

14.06.2018 16:00


Have you ever had career-orientated questions that you would like to ask a group leader? Such as the main decisions that led to their current career state or what are you expected to have for being selected for a postdoc position? During this session this kind of career-orientated questions will be discussed by a panel of junior and established IZN investigators:

Amit Agarwal, PhD
Research Group Leader since 2017

Carmen Ruiz de Almodóvar, PhD
Group Leader since 2011

Prof. Dr. Thomas Kuner, MD
Group Leader since 2000
 

 
Hosted by the
IZN PhD students
 

01 & 02.07.2018

IZN Retreat

 

The Gut-Brain Axis in Health and Disease

 

Kloster Schöntal

 

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Neurosciences Retreat

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Kloster Schöntal

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The Gut-Brain Axis in Health and Disease

01/02 July, 2018


Researchers discover receptor for the protein fragment APPsα mediating its physiological function

A cleavage product of the Alzheimer's APP protein stimulates nerve cell communication and memory. The protein fragment, known as APPsα, has neuroprotective properties and acts as a signal molecule on other nerve cells. But how does it influence brain functions?

An international research team led by Prof. Dr Ulrike Müller Externer Inhalt of the IZN has gained new insights into the molecular mechanism underlying its physiological functions. Full article...Externer Inhalt

Photo: Max Richter, Müller research group
Neuroprotective role of APPsα: A histological section through the hippocampus is depicted in the background. The red staining shows APPsα in neuronal cell bodies. The green staining shows the dendritic processes of nerve cells.


EMBL scientists discover how a molecule’s role changes from simple metabolite to instructive signal

ArendtAmong developmental biologists, the signalling molecule retinoic acid is well known for its role in building the vertebrate body. Not much is known, however, about how such signals emerge in evolution. To investigate this, the IZN's Arendt Externer Inhalt lab at EMBL in Heidelberg has studied the role of retinoic acid signalling in a marine worm. In the study published in Science Advances Externer Inhalt, the team and its collaborators show that in the worm, retinoic acid acts like a metabolic timer that helps neurons to form at the right time and place during development.

Image: Mette Handberg-Thorsager/EMBL


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IZN/Chica and Heinz Schaller Young Investigator Neuroscience Award

Call for Nominations for the 2018 Award

The IZN/Chica and Heinz Schaller Young Investigator Neuroscience Award is an annual prize offered by the Chica and Heinz Schaller Foundation and is given in recognition of an outstanding first-author research publication in any aspect of neuroscience. Candidates must be current members of IZN research groups or have been members while the relevant work was performed. IZN group leaders are excluded unless the work was clearly done during their post-doctoral or PhD period at IZN. Self-nomination of candidates is encouraged.

Deadline for nominations is May 31, 2018 and the award winner will be notified middle of June 2018. The prize money of 1,000 € is to be used at the winner’s or winners’ discretion and may be divided between equally contributing first authors. The prize will be presented at an award ceremony during the annual IZN Retreat, July 01-02, 2018, at Kloster Schöntal, where the successful candidate will make a 10-minute presentation of his/her work.

Applications should include:

  • CV
  • Scientific justification (one page, single spaced, Arial 11)
  • Summary of the significance of the work in lay terms (half a page, single spaced, Arial 11)
  • Original paper published or accepted for publication in 2017 or before May 31, 2018

Please send your application by email or Dropbox to Prof.Dr. Ricarda Diem (ricarda.diem@med.uni-heidelberg.de) on behalf of the IZN Award Selection Committee.


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Foundation BrainAid IZN Master’s Award

For the best Master’s Thesis in the Interdisciplinary Center for Neurosciences at Heidelberg University

Call for Nominations for the 2018 Award

The Foundation BrainAid IZN Master’s Award is an annual prize given in recognition of an outstanding Master’s Thesis in the Neurosciences. Candidates must be current members of IZN research groups or have been members while the relevant work was performed. Self-nomination of candidates is encouraged.

Deadline for self-nominations is May 31, 2018. The prize will be awarded during the annual IZN retreat, July 1-2, 2018, at Kloster Schöntal.

Applications should include:

  • CV
  • Scientific justification (one page, single spaced, Arial 11)
  • Summary of the significance of the work in lay terms (half a page, single spaced, Arial 11)
  • PDF of the Master Thesis completed in 2017 or before May 31, 2018

Please send your application by Email to the chair of the selection committee, Prof. Dr. Christoph Schuster (Schuster@nbio.uni-heidelberg.de).


 

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Open positions at the IZN

  • A PhD position is open at the Department of Neurophysiology lead by Prof. Treede to validate electrophysiological techniques on human models of pain. The main objective of the work is to improve the translatability of recordings in pain pathways of healthy subjects and preclinical species. The successful candidate will investigate the analgesic effects in the brain, the spinal cord and the peripheral nervous system. Adobe
    posted 05.2018
  • The research group of Dr. Sidney Cambridge (Department of Functional Neuroanatomy, Prof.Dr. Thomas Kuner) is looking for a highly motivated and well-trained student (f/m) for a Masters research project in cellular neurophysiology. The project will involve genetic manipulation of neuronal activity in a small population and assessing network changes in activity as compensatory homeostatic mechanisms. Adobe
    posted 05.2018
  • A PhD position in Neurobiology and Alzheimer Research is available in the laboratory of Prof. Ulrike Müller Externer Inhalt studying the synaptic roles of the APP gene family and their processing products. Techniques employed include state-of-the-art molecular biology, biochemistry, imaging and work with genetically modified mouse mutants (gain and loss of function studies) and viral vectors. Adobe
    posted 04.2018
  • The Ruiz de Almodóvar group is interested in the mechanisms of neurovascular development in mice and is looking for a motivated HiWi student to help with basic experimental techniques such as mouse genotyping, cell culture and histology. Adobe
    posted 03.2018
  • The Developmental Neurobiology group of Prof. Elisabeth Pollerberg is looking for a highly motivated postdoc whose project will focus on the interactions of cell adhesion molecules with other types of proteins and the impact of these interactions on axon elongation and navigation. Substantial amounts of data have already been collected for several projects and the postdoc is expected to complete and publish these studies. In addition, a new translational project could be started aiming at the improvement of axon regeneration. Adobe
    posted 02.2018
  • The laboratory of Dr. Amit Agarwal at the Institute for Anatomy and Cell Biology is offering 2 PhD positions in neuroscience and physiology. The work will combine molecular, optophysiological and advanced microscopic techniques, novel mouse genetics tools, single-cell gene expression methodologies and machine-learning-based computational approaches to decipher cellular connectivity and molecular pathways by which neurons and glia interact, interconnect and integrate into the neural networks.  Adobe
    posted 01.2018
  • The research group of Kevin Allen is seeking a highly motivated master student to work on the neuronal basis of spatial behaviour. The group is based within the Department of Clinical Neurobiology, Medical Faculty Heidelberg and DKFZ. Adobe
    posted 10.2017
  • A postdoc/scientific assistant position is offered in General Neurophysiology (Prof. Dr. Oliver Kann Externer Inhalt) at the Institute of Physiology and Pathophysiology, University of Heidelberg.
    The group of Professor Kann focuses on (i) the neuronal energy metabolism and (ii) the impact of brain macrophages (microglial cells) on neuronal activity under physiological and pathophysiological conditions. The future position holder will carry out an own research project within one of the two research focuses of the group.  Adobe posted 07.2017
  • The Department of Cellular and Molecular Pathology, DKFZ Heidelberg (Prof. Dr. H.-J. Gröne, sub-group Viola Nordström Externer Inhalt) is seeking two exceptionally motivated and skilled students (m/f) for Master theses in Neurobiology, offering the possibility to investigate the regulatory membrane lipid microenvironment of Astrocytes in the fascinating field of obesity, neuroinflammation and Alzheimer’s disease (AD).  Adobe  posted 05.2017

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Contact

Managing Director:
Prof. Dr. Hilmar Bading
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8218
Fax:  +49 - 6221 - 54 6700
email:  Bading@nbio.uni-heidelberg.de

 

Coordinator:
Dr. Otto Bräunling
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8694, 56 39007
Fax:  +49 - 6221 - 54 6700
email:  Braeunling@nbio.uni-heidelberg.de

 

Administration & Information:
Irmela Meng
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8219
Fax:  +49 - 6221 - 54 6700
email:  Sekretariat@nbio.uni-heidelberg.de

Webmaster contact: WebmasterIZN@uni-heidelberg.de
Latest Revision: 2018-05-25
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