05.07.2017 13:00

IZN Seminar


Activating the regenerative potential of Müller glia cells in the medaka retina

Katharina Lust (AG Wittbrodt)


MOG-Enzephalomyelitis – a new disease entity

Brigitte Wildemann


Im Neuenheimer Feld 306



IZN Retreat:

Evolution of Cognitive Abilities

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IZN/Chica and Heinz Schaller Young Investigator Neuroscience Award

Second Call for Nominations for the 2017 Award

The IZN/Chica and Heinz Schaller Young Investigator Neuroscience Award is an annual prize offered by the Chica and Heinz Schaller Foundation and is given in recognition of an outstanding first-author research publication in any aspect of neuroscience. Candidates must be current members of IZN research groups or have been members while the relevant work was performed. IZN group leaders are excluded unless the work was clearly done during their post-doctoral or PhD period at IZN. Self-nomination of candidates is encouraged.

Deadline for nominations has been extended to June 30, 2017 and the award winner will be notified at the beginning of July 2017. The prize money of 1,000 € is to be used at the winner’s or winners’ discretion and may be divided between equally contributing first authors. The prize will be presented at an award ceremony during the annual IZN Retreat, July 09-10, 2017, at Kloster Schöntal, where the successful candidate will make a 10-minute presentation of his/her work.

Applications should include:

  • A CV
  • Scientific justification (one page, single spaced, Arial 11)
  • Summary of the significance of the work in lay terms (half a page, single spaced, Arial 11)
  • Original paper published or accepted for publication in 2016 or before May 31, 2017

Please send your application by email or Dropbox to Prof.Dr. Ricarda Diem (ricarda.diem@med.uni-heidelberg.de) on behalf of the IZN Award Selection Committee.  Adobe

Blocking cancer-specific mutations in leukemia and brain tumors

Leukemia and brain cancer in mice slowed down

Vondeimling Many malignancies develop as a result of genetic alterations in individual cells. These gene mutations often cause altered proteins that give new, growth-promoting properties to the cell. A prime example for this principle is a cancer-related altered form of the IDH1 enzyme that was initially discovered in certain malignant brain tumors.

The 132 mutation of IDH1 has been found by now not only in various types of brain cancer (oligodendroglioma, diffuse astrocytoma and a smaller portion of glioblastomas) but also in approximately ten percent of acute myeloid leukemias (AML) as well as in bile duct cancer and certain malignant bone tumors. In two currently published studies, the Heidelberg researchers have now demonstrated the preclinical activity of BAY1436032 against AML and brain tumors (astrocytoma) in mice.

Under treatment with BAY1436032, mice that had been transplanted human astrocytoma cells survived significantly longer than untreated fellows. The agent, which can be administered with the food, substantially reduced the levels of the cancer-promoting metabolite in the cancer. "Even at high doses the animals tolerated the treatment well," said Andreas von Deimling, who is the head of a Clinical Cooperation Unit at the DKFZ and at Heidelberg University Hospital. "BAY1436032 really seems to act specifically on the mutated IDH1 in the cancer cells."  [More…]

Auszeichnung für den Heidelberger Mediziner Dr. Matthias Osswald

Der Mediziner Dr. Matthias Osswald hat den mit 100.000 Euro dotierten Hella-Bühler-Preis 2016 erhalten. Die von der Ruperto Carola vergebene Auszeichnung wendet sich an junge Forscher am Wissenschaftsstandort Heidelberg, die bereits durch herausragende wissenschaftliche Qualität in der Krebsforschung auf sich aufmerksam gemacht haben. Das Preisgeld dient dazu, ihre innovativen Arbeiten weiter zu fördern. Dr. Osswald forscht am Universitätsklinikum Heidelberg und am Deutschen Krebsforschungszentrum (DKFZ) zur Kommunikation und Netzwerkbildung zwischen den Zellen bösartiger Hirntumore.

Matthias Osswald (Jahrgang 1982) studierte Medizin an der Universität Freiburg, an der er auch mit einer Arbeit auf dem Gebiet der experimentellen Epilepsieforschung promoviert wurde. Der Mediziner ist Assistenzarzt an der Neurologischen Klinik des Universitätsklinikums Heidelberg; aktuell ist er für ein Jahr als Weiterbildungsassistent an der Klinik für Allgemeine Psychiatrie des Klinikums tätig. Seit 2011 forscht Dr. Osswald zudem als Postdoktorand in der Klinischen Kooperationseinheit Neuroonkologie, die am DKFZ angesiedelt ist. Im vergangenen Jahr wurde er mit dem IZN Chica and Heinz Schaller Young Investigator Neuroscience Award ausgezeichnet. [Mehr…]
Foto: Rothe

Not just amyloid: physiological functions of the amyloid precursor protein family

MuellerAmyloid precursor protein (APP) has been heavily implicated in Alzheimer disease, but the physiological roles of APP and the related APP-like proteins (APLPs) remain less well understood. In Nature Reviews Neuroscience, Urike Müller et al examine the functions of the APP family and its fragments in CNS development, synaptic function, brain injury and ageing.

Kloster 09.-10.07.2017:

IZN Retreat:

Evolution of Cognitive Abilities



Open positions at the IZN

  • The Department of Cellular and Molecular Pathology, DKFZ Heidelberg (Prof. Dr. H.-J. Gröne, sub-group Viola Nordström Externer Inhalt) is seeking two exceptionally motivated and skilled students (m/f) for Master Theses in Neurobiology, offering the possibility to investigate the regulatory membrane lipid microenvironment of Astrocytes in the fascinating field of obesity, neuroinflammation and Alzheimer’s disease (AD).  Adobe  posted 05.2017
  • A master thesis position is available in the laboratory of Carmen Ruiz de Almodóvar Externer Inhalt studying the role of Angiopoietins in the developing cerebellum.  Adobe  posted 04.2017
  • A postdoctoral position in Neurobiology and Alzheimer Research is available in the laboratory of Prof. Ulrike Müller Externer Inhalt (IPMB, Department of Functional Genomics) studying the synaptic role of the APP gene family and their processing products in transgenic animal models.  Adobe  posted 02.2017
  • Two PhD positions are offered in Developmental Neurobiology (Prof G.E. Pollerberg Externer Inhalt) to focus on new cell adhesion molecule (CAM)-interaction partners which we identified and analyze the functional impact of these interactions on axon growth. The projects are basic research but also aim at contributing to the development of novel therapeutic approaches.  Adobe  posted 02.2017



Managing Director:
Prof. Dr. Hilmar Bading
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8218
Fax:  +49 - 6221 - 54 6700
email:  Bading@nbio.uni-heidelberg.de


Dr. Otto Bräunling
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8694, 56 39007
Fax:  +49 - 6221 - 54 6700
email:  Braeunling@nbio.uni-heidelberg.de


Administration & Information:
Irmela Meng
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8219
Fax:  +49 - 6221 - 54 6700
email:  Sekretariat@nbio.uni-heidelberg.de
Editor: Webmaster
Latest Revision: 2017-06-26
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