22.02.2017 13:00

Neurobiology Lecture:

 

Function of the sorting receptor Rer1 in Purkinje cells

 

Christoph Kaether
Fritz-Lipmann-Institut für Alternsforschung
Jena

 

Rer1 is a sorting receptor in the early secretory pathway that controls the assembly and the cell surface transport of selected multimeric membrane protein complexes. Mice with a Purkinje cell (PC) specific deletion of Rer1 showed normal polarization and differentiation of PCs and normal development of the cerebellum. However, PC-specific loss of Rer1 led to age-dependent motor deficits in beam walk, ladder climbing and gait. Analysis of brain sections revealed a specific degeneration of PCs in the anterior cerebellar lobe in old animals. Electrophysiological recordings demonstrated strongly reduced capacities of PCs to generate the constant firing rates essential for normal function. Measurements of resurgent currents indicated decreased surface densities of voltage-gated sodium channels (Nav), but not changes in individual channels. Western Blot of mice with a CNS-specific Rer1-deletion demonstrated a strong down-regulation of Nav1.6 and 1.1 in the absence of Rer1, whereas protein levels of the related Cav2.1 channel were not affected. The data suggest that in PCs Rer1 controls the assembly and transport of Nav1.1 and 1.6, the principal sodium channels responsible for recurrent firing.

 

HS2
Im Neuenheimer Feld 306
Heidelberg

 
01.03.2017 13:00

Neurobiology Lecture:

 

The baker, sugar, and the molecular basis of Parkinson's disease

 

Tiago Fleming Outeiro
Department of Neurodegeneration and Restorative Research,
University Medical Center,
Göttingen

 

Aggregation of alpha-synuclein (ASYN) in Lewy bodies and Lewy neurites is the typical pathological hallmark of Parkinson’s disease (PD) and other synucleinopathies. Furthermore, mutations in the gene encoding for ASYN are associated with familial and sporadic forms of PD, suggesting this protein plays a central role in the disease. However, the precise contribution of ASYN to neuronal dysfunction and death is unclear. There is intense debate on the nature of the toxic species of ASYN, and little is still known about the molecular determinants of oligomerization and aggregation of ASYN in the cell. Using the budding yeast as a living test tube, we are making progress towards the understanding of the basic molecular mechanisms underlying PD and other synucleinopathies. In order to clarify the effects of different posttranslational modifications on the toxicity and aggregation of ASYN, we employ a variety of model systems. Phosphorylation and glycation are emerging as important modifications affecting ASYN aggregation. Altogether, our data shed light into the molecular underpinnings of PD, and open novel perspectives for therapeutic intervention in synucleinopathies.

 

HS2
Im Neuenheimer Feld 306
Heidelberg

 
08.03.2017 13:00

Neurobiology Lecture:

 

Fast inhibitory synapses: Release mechanisms, long-term plasticity and possible roles in circuit wiring

 

Ralf Schneggenburger
Ecole Polytechnique Fédérale de Lausanne (EPFL)
Brain Mind Institute
Laboratory of Synaptic Mechanisms (LSYM)
Lausanne, Switzerland

 

Our lab is interested in transmitter release mechanisms at synapses, and how the coordinated activity and plasticity at excitatory and inhibitory synapses might influence the wiring of specific circuits in the developing mammalian brain. Parvalbumin (PV)-expressing neurons across various brain regions are distinguished by extremely fast electrical and synaptic signalling; furthermore, PV-interneuron plasticity has been implicated in network plasticity and learning. I will show that PV-expressing inhibitory neurons use the Ca2+ sensor Synaptotagmin-2 (Syt2), but that Syt1 has a strongly overlapping role in these neurons. This indicates a Syt1 - Syt2 isoform switch in PV-interneurons. I will then present studies in the primary auditory cortex, where we investigate the spike-timing-dependent plasticity at GABAergic output synapses of PV-interneurons. These fast-signalling inhibitory synapses express robust and bi-directional long-term plasticity (iLTP and iLTD), regulated by spike-timing order and an intricate interaction between BDNF- and GABAB receptor signalling. I will discuss how iLTD and GABAB signalling might create windows of opportunity for plasticity at excitatory synapses. This could allow a use-dependent control of wiring decisions during critical periods of auditory cortex development by inhibitory plasticity.

 

HS2
Im Neuenheimer Feld 306
Heidelberg

 

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Rohini Kuner is a Feldberg Foundation Prizewinner for 2018

Kuner RThe purpose of the Foundation is the promotion of scientific contact between German and English scientists within the sphere of experimental medical research, in particular in physiology, pharmacology and related topics, primarily by the establishment of scientific exchange lectures.

Each year a German and a British scientist are chosen to receive a prize, the amount of which is an indication of Feldberg's wish that the recipients should be outstanding in their particular field.

Prof. Kuner’s research interests span neurobiological mechanisms underlying chronic pain disorders, elucidation of neural circuits mediating pain and other neurological disorders, cell-cell interactions in the nervous system and development of new strategies for pharmacological therapies. She is particularly known for her work on the molecular neurobiology of pain and has received several national and international scientific awards for uncovering key molecules mediating pain of inflammatory, neuropathic or cancer origin.  [More...Externer Inhalt]


Christian Thome has received the prestigious Ruprecht-Karls-Preis of Heidelberg University for 2016

The prize has been donated by the “Stiftung Universität Heidelberg“. It highlights the 5 best dissertations of the university in each year. Christians work dealt with structure and function of hippocampal pyramidal neurons. His key discovery is that in about 50% of CA1 pyramidal cells the Axon originates from a basal dendrite, rather than from the soma. Together with his colleagues in Heidelberg, Mannheim and Bonn he has characterized this unexpected morphological feature and its functional consequences. Indeed, the axon-carrying dendrite is privileged in exciting the axon, creating a fundamental asymmetry in dendritic integration. The work may, therefore, have important consequences for understanding signaling and information processing in the hippocampal network.  Externer Inhalt

Photo: Dr. Christian Thome together with his thesis advisors Prof. Andreas Draguhn and Dr. Alexei Egorov


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IZN Book Prize for the Best Master Thesis in the Neurosciences

Call for Nominations for the 2017 Award

The IZN Book Prize is an annual prize offered by the Foundation BrainAid and is given in recognition of an outstanding Master Thesis in the Neurosciences. Candidates must be current members of IZN research groups or have been members while the relevant work was performed. Self-nomination of candidates is encouraged.

Deadline for nominations is May 31, 2017. The prize will be awarded during the annual IZN retreat, July 09 -10, 2017, at Kloster Schöntal.

Applications should include:

  • CV
  • Scientific justification (one page, single spaced, Arial 11)
  • Summary of the significance of the work in lay terms (half a page, single spaced, Arial 11)
  • PDF File of the Master Thesis completed in 2016 or before May 31, 2017

Please send your application by Email to the chair of the selection committee, Prof.Dr. Christoph Schuster (Schuster@nbio.uni-heidelberg.de).


Izn Logo Chs Logo2016 Cmyk Pfade English2

IZN/Chica and Heinz Schaller Young Investigator Neuroscience Award

Call for Nominations for the 2017 Award

The IZN/Chica and Heinz Schaller Young Investigator Neuroscience Award is an annual prize offered by the Chica and Heinz Schaller Foundation and is given in recognition of an outstanding first-author research publication in any aspect of neuroscience. Candidates must be current members of IZN research groups or have been members while the relevant work was performed. IZN group leaders are excluded unless the work was clearly done during their post-doctoral or PhD period at IZN. Self-nomination of candidates is encouraged.

Deadline for nominations is May 30, 2017 and the award winner will be notified at the end of June 2017. The prize money of 1,000 € is to be used at the winner’s or winners’ discretion and may be divided between equally contributing first authors. The prize will be presented at an award ceremony during the annual IZN Retreat, July 09-10, 2017, at Kloster Schöntal, where the successful candidate will make a 10-minute presentation of his/her work.

Applications should include:

  • A CV
  • Scientific justification (one page, single spaced, Arial 11)
  • Summary of the significance of the work in lay terms (half a page, single spaced, Arial 11)
  • Original paper published or accepted for publication in 2016 or before May 31, 2017

Please send your application by email or Dropbox to Prof.Dr. Ricarda Diem (ricarda.diem@med.uni-heidelberg.de) on behalf of the IZN Award Selection Committee.  Adobe


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Open positions at the IZN

  • A postdoctoral position in Neurobiology and Alzheimer Research is available in the laboratory of Prof. Ulrike Müller Externer Inhalt (IPMB, Department of Functional Genomics) studying the synaptic role of the APP gene family and their processing products in transgenic animal models.  Adobe  posted 02.2017
  • Two PhD positions are offered in Developmental Neurobiology (Prof G.E. Pollerberg Externer Inhalt) to focus on new cell adhesion molecule (CAM)-interaction partners which we identified and analyze the functional impact of these interactions on axon growth. The projects are basic research but also aim at contributing to the development of novel therapeutic approaches.  Adobe  posted 02.2017
  • One postdoc position is immediately available in Neurobiology (Dr. C. Ciccolini Externer Inhalt). The group is interested in understanding how primary cilia regulate the proliferation of adult neural stem cells. Adobe  posted 01.2017
  • One PhD position is offered in Neurobiology (Prof R. Rudolf Externer Inhalt) to focus on the newly discovered sympathetic co-innervation of vertebrate neuromuscular junctions: development - biomedical relevance - mechanisms of action.  Adobe  posted 10.2016

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Managing Director:
Prof. Dr. Hilmar Bading
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8218
Fax:  +49 - 6221 - 54 6700
email:  Bading@nbio.uni-heidelberg.de

 

Coordinator:
Dr. Otto Bräunling
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8694, 56 39007
Fax:  +49 - 6221 - 54 6700
email:  Braeunling@nbio.uni-heidelberg.de

 

Administration & Information:
Irmela Meng
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8219
Fax:  +49 - 6221 - 54 6700
email:  Sekretariat@nbio.uni-heidelberg.de
Editor: Webmaster
Latest Revision: 2017-02-17
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