25.07.2014 15:00

BCCN Seminar:

Probing the limits of a detailed, data-driven network model of the prefrontal cortex

Joachim Hass
Department of Theoretical Neuroscience, ZI, Mannheim;
BCCN Heidelberg-Mannheim

A major challenge in computational neuroscience is to derive neuronal network models that are both physiologically realistic, and computationally tractable. Towards this goal, we constructed a computational network model of the prefrontal cortex (PFC) based on simple single neuron elements, yet equipped with highly realistic anatomy and close fitting of cellular and synaptic parameter distributions derived from an extensive data base of prefrontal in vitro and in vivo recordings.

Even without any tuning, the network model manages to reproduce a number of statistics extracted from in vivo data from awake behaving rats. We tested to which extend this result is affected by the parameters of the model, namely the constant background currents driving the network activity, the synaptic peak conductances and time constants, the reversal potential of the GABA current, and the distributions of neuron parameters extracted from the in vitro data. The network showed robustness against small changes in all tested parameters, but the comparison with the in vivo data also allowed to constrain the range of admissible values for several of them.

In summary, we have generated a PFC network model which is biologically highly valid, yet still reasonably fast to simulate and fit, and can now be exploited to probe the impact of pharmacological or genetic conditions on network dynamics, and to model performance in PFC-dependent tasks.


CIMH Mannheim, Therapy Building, big lecture hall


IZN Seminar:



Electrical activity in sensory axonal regeneration

Ioana Goganau (AG Blesch)



Parvalbumin interneurons provide grid cell-driven recurrent inhibition in the medial entorhinal cortex

Christina Bütfering (AG Monyer)


HS2, Im Neuenheimer Feld 306

17.09.2014 13:00

Neurobiology Lecture:


Carlos Dotti, Leuven, Belgium


HS2, Im Neuenheimer Feld 306


Welcome to the IZN Home Page

Selected cells
Kuner T Fig1
Pauen Fig1
Poggi Figure2
Rappold Fig1
Holstein Fig1

German National Brain Bee was record breaking in 2014

The three Heidelberg University neuroscientists who served as judges were Prof. Dr. Armin Blesch, Director of the Laboratory for Neuroregeneration at the Spinal Cord Injury Center, Prof. Dr. Stephan Frings, Coordinator of the Interdisciplinary Neurosciences Centre Masters Program, and Dr. Lucia Poggi of the Neurodevelopment Division of the Centre for Organismal Studies. Externer Inhalt


Zentralinstitut für Seelische Gesundheit (ZI): Verleihung des Prix ROGER DE SPOELBERCH an Professor Meyer-Lindenberg

Meyer-lindenbergProfessor Andreas Meyer-Lindenberg, Direktor des ZI sowie Ärztlicher Direktor der Klinik für Psychiatrie und Psychotherapie, erhielt am 25. April 2014 in Genf den mit 750.000 Euro dotierten Prix ROGER DE SPOELBERCH 2013. Der Preis würdigt das wissenschaftliche Gesamtwerk von Professor Meyer-Lindenberg im Bereich der klinischen psychiatrischen Forschung. Externer Inhalt


Aktuelle Forschungsfragen auf dem Gebiet der Neuroökonomie, einer interdisziplinären Verknüpfung von Neuro- und Wirtschaftswissenschaften, diskutieren an der Universität Heidelberg herausragende junge Forscher aus Asien, Europa und Lateinamerika

ScnellDie wissenschaftliche Leitung der Veranstaltung liegt bei Prof. Dr. Christiane Schwieren vom Alfred-Weber-Institut für Wirtschaftswissenschaften, Dr. Malte Stopsack vom Psychologischen Institut und Privatdozent Dr. Knut Schnell vom Zentrum für Psychosoziale Medizin am Universitätsklinikum Heidelberg, in Zusammenarbeit mit Dr. Santiago Sánchez Pagés von der Universitat de Barcelona. Externer Inhalt



Open positions at the IZN

  • The group of Ana Oliveira at the Department of Neurobiology (Prof. H. Bading) is offering a Postdoctoral position investigating the molecular mechanisms of Learning and Memory. Adobe
  • The group of Ana Oliveira at the Department of Neurobiology (Prof. H. Bading) is offering a PhD position studying the role of DNA methylation in memory formation. Adobe


Managing Director:
Prof. Dr. Hilmar Bading
Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8218
Fax:  +49 - 6221 - 54 6700
eMail:  Hilmar.Bading@uni-hd.de


Dr. Otto Bräunling
Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8694, 56 39007
Fax:  +49 - 6221 - 54 6700
eMail:  Braeunling@uni-hd.de


Administration & Information:
Dipl.-Biol. Ute Volbehr
IZN, University of Heidelberg
Im Neuenheimer Feld 326, 3.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 6498 mornings
  +49 - 6221 - 54 8227 afternoons
Fax:  +49 - 6221 - 54 4561
eMail:  izn@uni-hd.de
Editor: Webmaster
Latest Revision: 2014-07-24
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