19.12.2014

BCCN Lecture

15:00

Spike-time autocorrelation reveals functional distinct cell groups in the medial entorhinal cortex

Patrick Latuske
Department of Clinical Neurobiology, Medical Faculty of Heidelberg University
and
German Cancer Research Center (DKFZ), Heidelberg

 

The superficial layers of the medial entorhinal cortex (MEC) contain a variety of spatially selective cell types that are thought to generate a metric representation of space. A prominent cell type there are grid cells that exhibit a regular, hexagonal firing pattern when an animal runs in an open environment. Anatomically, excitatory neurons in the MEC show high degree of variability ranging from stellate cells to pyramidal cells, and including several intermediate types in between. Here we investigated whether principal neurons recorded with extracellular techniques in the superficial layers of the MEC can be grouped into distinct groups based on their spike patterns at a millisecond time scale. Factor analysis of the spike-time autocorrelation revealed at least two groups, labelled bursty and non-bursty neurons, which also exhibit different spike waveforms. Bursty neurons were twice as likely to be classified as a grid cells compared to non-bursty neurons. Moreover, 70 % of the detected monosynaptic excitatory connections between principal cells and interneurons originate from bursty neurons. Together, these results suggest that bursty and non-bursty neurons form distinct neuronal populations differing in biophysical properties and network functions.

SR14
Im Neuenheimer Feld 306
69120 Heidelberg

 
07.01.2015

Neurobiology Lecture

13:00

When pain and reward are simultaneously present: perception, motivation and underlying brain mechanisms

Susanne Becker, Mannheim

 

HS2
Im Neuenheimer Feld 306
69120 Heidelberg

 
09.01.2015

BCCN Lecture

15:00

Prof. Randy McIntosh
Director Rotman Research Institute, Vice President of Research,
Baycrest Centre, Reva James Leeds Chair in Neuroscience &
Research Leadership, Toronto, Canada

 

ZI, Big Lecture Hall, Therapy Building, J5, Mannheim

 

Welcome to the IZN Home Page

Selected cells
Kuner T Fig1
Pauen Fig1
Poggi Figure2
Rappold Fig1
Holstein Fig1
 

IZN Retreat 2014: "Neuroscience Perspectives – Transition from Science to Industry and Back"

2014poster"We all agree that we had an interesting and exciting retreat again this year at beautiful Kloster Schöntal, and would like to take a brief moment here to thank all those who contributed to the success of this event.

First, we give many thanks to all participants and speakers; your interesting contributions and discussions truly made it a fruitful and stimulating meeting.

Our special thanks go to the scientific organizing committee, Viola Nordstöm, Valery Grinevich and Wolfgang Sommer.

We would also like to say thank you to the graduate and undergraduate students who provided excellent technical help throughout the meeting, especially to Fabian Roth.

Our gratitude goes also to Teresa Weiß and Otto Bräunling who were heavily involved in organizing the IZN Retreat.

Last but not least, the whole IZN Retreat would not be possible without the organizing talent and dedicated engagement of Ute Volbehr, to whom we are also very grateful.

For the IZN directors

Hilmar Bading"


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Prizes for the best posters of the IZN Retreat

Silke Herzer (AG Nordström)
Silke Herzer, Sascha Meldner, Hermann-Josef Gröne and Viola Nordström:
"Inhibition of glucosylceramide synthase (GCS) enhances neuronal resistance towards amyloid-beta (Aβ)-mediated toxicity"

Frauke Leitner (AG Monyer and Seeburg)
Frauke C. Leitner, Sarah Melzer, Elke C. Fuchs, Henry Lütcke, Fritjof Helmchen, Peter H. Seeburg, Hannah Monyer:
"Functional and anatomical investigation of neuronal subpopulations in the lateral entorhinal cortex"

Thekla Hemstedt (AG Bading)
Thekla J. Hemstedt, Ana M.M. Oliveira and Hilmar Bading:
"Nuclear calcium-regulated dendritic morphology controls neuronal permissiveness for long-term behavioural adaptations"

Ferdinand Althammer (AG Grinevich)
Ferdinand Althammer, Apar Jain, Miriam Kernert, H. Sophie Knobloch, Anna Illarionova, Hilmar Bading, Rolf Sprengel, Peter H. Seeburg, Mazahir T. Hasan, Valery Grinevich:
"Probing functional specialization of the oxytocin system in two paradigms of fear conditioning"


Der SFB "Funktionelle Ensembles: Integration von Zellen, Genese von Aktivitätsmustern und Plastizität von Gruppen ko-aktiver Neurone in lokalen Netzwerken" wurde für zunächst vier Jahre eingerichtet.

draguhn.jpgSprecher ist Professor Dr. Andreas Draguhn, Direktor der Abteilung Neuro- und Sinnesphysiologie am Institut für Physiologie und Pathophysiologie der Medizinischen Fakultät Heidelberg.

Das menschliche Nervensystem besteht aus rund 100 Milliarden Nervenzellen, zwischen denen es unzählige Verbindungen und Signalwege gibt. "Dennoch ist unser Verhalten, sind unsere Bewegungen, Gedanken und Gefühle reproduzierbar - das heißt die Aktivität der Nervenzellen muss trotz ihrer unendlichen Komplexität stabilen und reproduzierbaren Mustern folgen", erläutert Professor Draguhn. Zentrale Hypothese des neuen SFB ist, dass Nervenzellen sich zu neuronalen Ensembles verbinden, die stabil wiederholbare raumzeitliche Muster bilden und die Grundlage unseres verlässlichen Verhaltens sind. Externer Inhalt


Seit Oktober 2014 leitet der renommierte Neuroonkologe Professor Dr. Wolfgang Wick als Ärztlicher Direktor die Neurologische Universitätsklinik Heidelberg

W.WickMit dem Leitungswechsel sind zum 1. Oktober die beiden Abteilungen Allgemeine Neurologie und Neuroonkologie zur Abteilung Neurologie und Poliklinik zusammengelegt worden. Diese verfügt insgesamt über 86 Betten und deckt die Bereiche Neuroonkologie, Neuroimmunologie, Neurologische Intensivmedizin und Vaskuläre Neurologie mit der Schlaganfallstation ab. "Unsere Schwerpunkte in der Patientenversorgung und Forschung bleiben erhalten, wenn sich auch die Struktur etwas geändert hat", betont Professor Wick. "Wir wollen allerdings die Umstrukturierung nutzen, um die Betreuung unserer Patienten in einigen Punkten weiter zu verbessern." Externer Inhalt


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Open positions at the IZN

  • The Nordström group is offering a master project in neurobiology to investigate the regulatory membrane lipid microenvironment in the fascinating field of Alzheimer’s Disease (AD). Adobe
    12.2014-01.2015

 

  • The Pollerberg group is offering a PhD position in a project studying the role of cell adhesion molecules (CAMs) and their interaction partners for axon growth and regeneration. Adobe
    08.-11.2014

 

  • The Pollerberg group is offering a PhD position in a project studying the role of microtubules and microtubule-associated proteins for axon growth and navigation. Adobe
    08.-11.2014

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Managing Director:
Prof. Dr. Hilmar Bading
Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8218
Fax:  +49 - 6221 - 54 6700
eMail:  Hilmar.Bading@uni-hd.de

 

Coordinator:
Dr. Otto Bräunling
Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8694, 56 39007
Fax:  +49 - 6221 - 54 6700
eMail:  Braeunling@uni-hd.de

 

Administration & Information:
Dipl.-Biol. Ute Volbehr
IZN, University of Heidelberg
Im Neuenheimer Feld 326, 3.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 6498 mornings
  +49 - 6221 - 54 8227 afternoons
Fax:  +49 - 6221 - 54 4561
eMail:  izn@uni-hd.de
Editor: Webmaster
Latest Revision: 2014-12-17
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