26.04.2017 13:00

Neurobiology Lecture

 

Mechanisms of neuronal gene expression in axonal regeneration and traumatic brain injury

Prof. Dr. Bernd Knöll
Institut für Physiologische Chemie
Universität Ulm

 

The presentation will cover roles of the transcription factors SRF (serum response factor) and ATF3 (activating transcription factor 3) in rodent brain injury models. The latter include drop-tower-based traumatic brain injury and peripheral nerve regeneration models such as facial nerve injury. Using mouse mutants for these transcription factors we uncovered functions of these gene regulators in injury-related gene expression, behavior and neuronal de- and regeneration.

 

 

HS2
Im Neuenheimer Feld 306
Heidelberg

 

03.05.2017 13:00

Neurobiology Lecture

 

Lighting up the axon initial segment with Chandelier cells

Winnie Wefelmeyer
King’s College,
London, UK

 

HS2
Im Neuenheimer Feld 306
Heidelberg

 

09.-10.07.2017

IZN Retreat:

Evolution of Cognitive Abilities
 

Welcome to the IZN Home Page
Selected cells
Kuner T Fig1
Pauen Fig1
Poggi Figure2
Rappold Fig1
Holstein Fig1

Not just amyloid: physiological functions of the amyloid precursor protein family

MuellerAmyloid precursor protein (APP) has been heavily implicated in Alzheimer disease, but the physiological roles of APP and the related APP-like proteins (APLPs) remain less well understood. In Nature Reviews Neuroscience, Urike Müller et al examine the functions of the APP family and its fragments in CNS development, synaptic function, brain injury and ageing.

Peptid vermittelt das Lernen

​​http://www.dkfz.de/__we_thumbs__/62143_1_Dumitru-et-al.jpg?m=1491405268
© Ionut Dumitru, DKFZ​​
​Die Fähigkeit des Gehirns, auf Veränderungen zu reagieren und sich diesen anzupassen, bezeichnen Wissenschaftler als Plastizität. Diese Fähigkeit ist die Grundlage aller Lernprozesse. Einen wesentlichen Beitrag dazu leisten neue Nervenzellen, die auch beim Erwachsenen in bestimmten Bereichen des Gehirns entstehen können.

„Wir wussten aber bisher nicht, über welche molekularen Prozesse veränderte Umweltbedingungen in die Produktion neuer Nervenzellen übersetzt werden", erklärt Hannah Monyer, Leiterin der Kooperationsabteilung Klinische Neurobiologie des Deutschen Krebsforschungszentrums und des Universitätsklinikums Heidelberg. „Mit unserer aktuellen Arbeit haben wir erstmals einen wichtigen Vermittler in diesem Prozess gefunden." [Mehr...]

Bildung neuer Nervenzellen im Hippocampus der Maus. DBI (Diazepam binding inhibitor) ist rot gefärbt, die beiden Stammzellmarker Nestin und SOX2 sind grün und cyanblau markiert.


New insights into regulatory mechanisms help in understanding diseases of the central nervous system

ruizHeidelberg Neuroscientists have identified a critical regulator for blood vessel growth in the developing embryonic spinal cord. The research group under the direction of Dr. Carmen Ruiz de Almodóvar of the Heidelberg University Biochemistry Center discovered that special nerve cells known as motor neurons control this process. This new insight into the nature of the interrelationship between the nervous system and the vascular system will help in understanding diseases of the central nervous system. These findings were published in the journal "Nature Communications".  [Full article]


Höchste wissenschaftliche Auszeichnung Taiwans für Hannah Monyer

MonyerDer taiwanesische Wissenschaftsrat zeichnete Hannah Monyer vom Deutschen Krebsforschungszentrum und vom Universitätsklinikum Heidelberg für ihre bahnbrechenden Arbeiten zum Gedächtnis mit dem Tsungming Tu-Preis aus. Der Preis ist die höchste akademische Ehre Taiwans für ausländische Wissenschaftler und ist mit 75.000 Dollar dotiert.

Eine besondere Rolle für das Lernen und das Gedächtnis spielen die so genannten inhibitorischen Interneurone, die den Neurotransmitter GABA produzieren. Monyer konnte zeigen, wie diese Interneurone mit anderen Nervenzellen verschaltet sind und diese im Millisekundenbereich synchronisieren. Die synchrone Aktivität von Nervenschaltkreisen liegt den kognitiven Funktionen zugrunde.

Derzeit konzentriert sich die Neurowissenschaftlerin auf die Plastizität des Gehirns, also seine Anpassungsfähigkeit, die auf der Integration neu geborener Nervenzellen in bestehende Netzwerke beruht. Dazu untersucht sie Gene, die an Zellgeburt, Zellwanderung und Zelldifferenzierung beteiligt sind. [Mehr...]


Kloster 09.-10.07.2017:
 

IZN Retreat:

Evolution of Cognitive Abilities

IZNlogo

Izn Logo Foundationbrainaid

IZN Book Prize for the Best Master Thesis in the Neurosciences

Call for Nominations for the 2017 Award

The IZN Book Prize is an annual prize offered by the Foundation BrainAid and is given in recognition of an outstanding Master Thesis in the Neurosciences. Candidates must be current members of IZN research groups or have been members while the relevant work was performed. Self-nomination of candidates is encouraged.

Deadline for nominations is May 31, 2017. The prize will be awarded during the annual IZN Retreat, July 09 -10, 2017, at Kloster Schöntal.

Applications should include:

  • CV
  • Scientific justification (one page, single spaced, Arial 11)
  • Summary of the significance of the work in lay terms (half a page, single spaced, Arial 11)
  • PDF File of the Master Thesis completed in 2016 or before May 31, 2017

Please send your application by Email to the chair of the selection committee, Prof.Dr. Christoph Schuster (Schuster@nbio.uni-heidelberg.de).


Izn Logo Chs Logo2016 Cmyk Pfade English2

IZN/Chica and Heinz Schaller Young Investigator Neuroscience Award

Call for Nominations for the 2017 Award

The IZN/Chica and Heinz Schaller Young Investigator Neuroscience Award is an annual prize offered by the Chica and Heinz Schaller Foundation and is given in recognition of an outstanding first-author research publication in any aspect of neuroscience. Candidates must be current members of IZN research groups or have been members while the relevant work was performed. IZN group leaders are excluded unless the work was clearly done during their post-doctoral or PhD period at IZN. Self-nomination of candidates is encouraged.

Deadline for nominations is May 30, 2017 and the award winner will be notified at the end of June 2017. The prize money of 1,000 € is to be used at the winner’s or winners’ discretion and may be divided between equally contributing first authors. The prize will be presented at an award ceremony during the annual IZN Retreat, July 09-10, 2017, at Kloster Schöntal, where the successful candidate will make a 10-minute presentation of his/her work.

Applications should include:

  • A CV
  • Scientific justification (one page, single spaced, Arial 11)
  • Summary of the significance of the work in lay terms (half a page, single spaced, Arial 11)
  • Original paper published or accepted for publication in 2016 or before May 31, 2017

Please send your application by email or Dropbox to Prof.Dr. Ricarda Diem (ricarda.diem@med.uni-heidelberg.de) on behalf of the IZN Award Selection Committee.  Adobe


 

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Open positions at the IZN

  • A master thesis position is available in the laboratory of Carmen Ruiz de Almodóvar Externer Inhalt studying the role of Angiopoietins in the developing cerebellum.  Adobe  posted 04.2017
  • A postdoctoral position in Neurobiology and Alzheimer Research is available in the laboratory of Prof. Ulrike Müller Externer Inhalt (IPMB, Department of Functional Genomics) studying the synaptic role of the APP gene family and their processing products in transgenic animal models.  Adobe  posted 02.2017
  • Two PhD positions are offered in Developmental Neurobiology (Prof G.E. Pollerberg Externer Inhalt) to focus on new cell adhesion molecule (CAM)-interaction partners which we identified and analyze the functional impact of these interactions on axon growth. The projects are basic research but also aim at contributing to the development of novel therapeutic approaches.  Adobe  posted 02.2017

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Managing Director:
Prof. Dr. Hilmar Bading
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8218
Fax:  +49 - 6221 - 54 6700
email:  Bading@nbio.uni-heidelberg.de

 

Coordinator:
Dr. Otto Bräunling
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8694, 56 39007
Fax:  +49 - 6221 - 54 6700
email:  Braeunling@nbio.uni-heidelberg.de

 

Administration & Information:
Irmela Meng
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8219
Fax:  +49 - 6221 - 54 6700
email:  Sekretariat@nbio.uni-heidelberg.de
Editor: Webmaster
Latest Revision: 2017-04-24
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